Description

2-Bromo-5-Fluoro-3-(Methylthio)Pyridine is a high-value, multi-functional halogenated pyridine derivative used as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a methylthio substituent, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides, where the fluorine and bromine atoms contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and mechanisms.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-5-Fluoro-3-(Methylthio)Pyridine
CAS No.	1357946-44-1
Molecular Formula	C7H5BrFNS
Molecular Weight	222.09 g/mol
Synonyms	3-(Methylthio)-2-bromo-5-fluoropyridine; 5-Fluoro-2-bromo-3-methylthiopyridine; 2-Bromo-5-fluoro-3-methylsulfanylpyridine; Pyridine, 2-bromo-5-fluoro-3-(methylthio)-; 1357946-44-1; 2-Bromo-5-fluoro-3-(methylmercapto)pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoro-3-(Methylthio)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.