Description

Imidazole-1-Sulfonyl Azide Tetrafluoroborate is a specialized diazo transfer reagent used for the efficient synthesis of azides from primary amines. This compound matters because it offers a stable, crystalline, and safer alternative to traditional azide reagents like triflyl azide, enabling critical transformations in complex molecule assembly. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing nitrogen-rich scaffolds and conducting click chemistry.

Application

• Diazo Transfer Reactions: Key reagent for converting primary amines into organic azides under mild conditions.
• Pharmaceutical Intermediate Synthesis: Used in the preparation of triazoles and other nitrogen-containing heterocycles via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Peptide Modification: Facilitates the site-specific labeling and functionalization of peptides and proteins.
• Polymer & Materials Science: Enables the introduction of azide functional groups into polymers for cross-linking and surface modification.
• Agrochemical Research: Employed in the synthesis of novel active ingredients containing azide or triazole motifs.
• Chemical Biology Probes: Useful for synthesizing activity-based probes and bioconjugation handles.

Basic Information

Product Name	Imidazole-1-Sulfonyl Azide Tetrafluoroborate
CAS No.	1357503-31-1
Molecular Formula	C3H3BF4N5O2S
Molecular Weight	267.95 g/mol
Synonyms	Imidazole-1-sulfonyl azide tetrafluoroborate; Imidazylsulfonyl azide tetrafluoroborate; ISA-TFB; 1-Imidazolesulfonyl azide tetrafluoroborate salt; (Imidazole-1-sulfonyl)azidotetrafluoroborate; Diazo transfer reagent ISA-TFB; 1H-Imidazole-1-sulfonyl azide tetrafluoroborate(1-)
EINECS	Contact for details

Quality Control

Our Imidazole-1-Sulfonyl Azide Tetrafluoroborate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analytical testing, including NMR, HPLC, and elemental analysis, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.