Description

5-Amino-7-Oxa-2-Aza-Spiro[3.5]Nonane-2-Carboxylic Acid tert-Butyl Ester is a high-value, multifunctional spirocyclic building block essential for advanced organic synthesis. Its unique fused-ring structure containing amino, oxa, and aza functionalities makes it a critical intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including protease inhibitors and other biologically relevant heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced, high-performance crop protection agents with novel modes of action.
• Peptidomimetics & Constrained Peptides: Serves as a rigid, spirocyclic scaffold to introduce conformational restraint into peptide backbones, enhancing metabolic stability and binding affinity.
• Chemical Biology Probes: Employed in the synthesis of specialized molecular tools for studying enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for novel polymers with specific thermal or mechanical properties derived from its spirocyclic core.
• Academic & Process Chemistry: A valuable reagent for methodological studies in asymmetric synthesis and the development of new catalytic transformations.

Basic Information

Product Name	5-Amino-7-Oxa-2-Aza-Spiro[3.5]Nonane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1357354-13-2
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	tert-Butyl 5-amino-7-oxa-2-azaspiro[3.5]nonane-2-carboxylate; 2-Azaspiro[3.5]nonane-2-carboxylic acid, 5-amino-7-oxa-, 1,1-dimethylethyl ester; 5-Amino-7-oxa-2-azaspiro[3.5]nonane-2-carboxylic acid 1,1-dimethylethyl ester; 2-azaspiro[3.5]nonane-2-carboxylic acid, 5-amino-7-oxa-, tert-butyl ester; Boc-Protected 5-Amino-7-oxa-2-azaspiro[3.5]nonane; Spirocyclic β-Amino Ester Building Block
EINECS	Contact for details

Quality Control

Our 5-Amino-7-Oxa-2-Aza-Spiro[3.5]Nonane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with full chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.