Description

1,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid,3-Hydroxy-1-(Phenylmethyl)-,1,1-Dimethylethyl Ester is a sophisticated spirocyclic organic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a key chiral intermediate for constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel therapeutics, including central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in the design and synthesis of compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The spirocyclic and benzyl-protected amine structure makes it a valuable precursor for potential protease or kinase inhibitor candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or scaffold in stereoselective synthesis to introduce specific three-dimensional configurations into target molecules.
• Chemical Biology Probes: Useful for creating specialized molecular probes to study biological pathways and enzyme functions.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	1,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid,3-Hydroxy-1-(Phenylmethyl)-,1,1-Dimethylethyl Ester
CAS No.	1357353-34-4
Molecular Formula	C20H30N2O3
Molecular Weight	346.47 g/mol
Synonyms	tert-Butyl 3-hydroxy-1-benzyl-1,8-diazaspiro[4.5]decane-8-carboxylate; 1,8-Diazaspiro[4.5]decane-8-carboxylic acid, 3-hydroxy-1-(phenylmethyl)-, 1,1-dimethylethyl ester; 1-Benzyl-3-hydroxy-1,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 3-Hydroxy-1-benzyl-1,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 1,8-Diazaspiro[4.5]decane-8-carboxylate, tert-butyl 3-hydroxy-1-(phenylmethyl)-; BOC-1,8-Diazaspiro[4.5]decane derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under cGMP conditions for projects requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.