Description

1-Hydroxy-8-Aza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester is a sophisticated spirocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and bioactive molecules, particularly those targeting the central nervous system. Pharmaceutical R&D teams and fine chemical manufacturers need this high-purity intermediate to construct complex molecular architectures with precision.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing spirocyclic compound libraries in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a building block in the multi-step synthesis of complex target molecules.
• Chemical Biology Probes: Employed in the design and synthesis of probes for studying enzyme function and receptor interactions.
• Asymmetric Synthesis: Utilized in chiral synthesis due to its defined stereochemistry and functional group compatibility.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development.

Basic Information

Product Name	1-Hydroxy-8-Aza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester
CAS No.	1357352-29-4
Molecular Formula	C14H25NO3
Molecular Weight	255.36 g/mol
Synonyms	8-tert-Butoxycarbonyl-8-aza-1-hydroxyspiro[4.5]decane; 1-Hydroxy-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 1-hydroxy-8-azaspiro[4.5]decane-8-carboxylate; 8-Boc-8-aza-1-hydroxyspiro[4.5]decane; 1-Hydroxy-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester; 8-Azaspiro[4.5]decane-8-carboxylic acid, 1-hydroxy-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-8-Aza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.