Description

6-Oxa-2-Aza-Spiro[3.6]Decane-2-Carboxylic Acid tert-Butyl Ester (Wx100818) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional degrader molecules.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Used in university laboratories for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	6-Oxa-2-Aza-Spiro[3.6]Decane-2-Carboxylic Acid tert-Butyl Ester (Wx100818)
CAS No.	1357352-13-6
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	tert-Butyl 6-oxa-2-azaspiro[3.6]decane-2-carboxylate; 2-Aza-6-oxaspiro[3.6]decane-2-carboxylic acid, 1,1-dimethylethyl ester; 2-(tert-Butoxycarbonyl)-6-oxa-2-azaspiro[3.6]decane; Boc-6-Oxa-2-aza-spiro[3.6]decane; Wx100818; 1357352-13-6; Spirocyclic tert-butyl ester
EINECS	Contact for details

Quality Control

Our 6-Oxa-2-Aza-Spiro[3.6]Decane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.