Description

2-tert-Butyl 5-Ethyl 7-Oxo-2,6-Diazaspiro[3.4]Octane-2,5-Dicarboxylate CAS NO 1357351-87-1 is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic diazaoctane core structure. This compound is of significant value in modern medicinal chemistry, serving as a critical building block for the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates, especially those targeting protein-protein interactions.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new molecular entities with improved efficacy and safety profiles.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads in bifunctional degrader molecules.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying specific biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery.

Basic Information

Product Name	2-tert-Butyl 5-Ethyl 7-Oxo-2,6-Diazaspiro[3.4]Octane-2,5-Dicarboxylate
CAS No.	1357351-87-1
Molecular Formula	C15H24N2O5
Molecular Weight	312.36 g/mol
Synonyms	2,6-Diazaspiro[3.4]octane-2,5-dicarboxylic acid, 7-oxo-, 2-(1,1-dimethylethyl) 5-ethyl ester; 2-(tert-Butyl) 5-ethyl 7-oxo-2,6-diazaspiro[3.4]octane-2,5-dicarboxylate; 7-Oxo-2,6-diazaspiro[3.4]octane-2,5-dicarboxylic acid 2-tert-butyl 5-ethyl ester; tert-Butyl 5-ethyl 7-oxo-2,6-diazaspiro[3.4]octane-2,5-dicarboxylate; CAS 1357351-87-1; Spirocyclic diazaoctane derivative; BOC-Protected diazaspirooctane ester.
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl 5-Ethyl 7-Oxo-2,6-Diazaspiro[3.4]Octane-2,5-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 standards, and we can support development projects requiring materials produced under GMP (Good Manufacturing Practice) guidelines for non-clinical and clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.