Description

4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyridin-2-Amine is a high-value, organoboron-protected pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling the efficient construction of complex molecular architectures through versatile cross-coupling reactions, particularly Suzuki-Miyaura couplings. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing trifluoroethyl and pyridine motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic frameworks.
• Material Science Research: Building block for creating organic electronic materials, ligands for catalysts, and specialty polymers.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl/heteroaryl halides.
• Medicinal Chemistry & Library Synthesis: Enables rapid parallel synthesis and structure-activity relationship (SAR) studies for lead optimization.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes and labeled compounds for biochemical assays.

Basic Information

Product Name	4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyridin-2-Amine
CAS No.	1356699-53-0
Molecular Formula	C14H20BF3N2O2
Molecular Weight	316.13 g/mol
Synonyms	2-Amino-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2,2-trifluoroethyl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-N-(2,2,2-trifluoroethyl)pyridin-2-amine; 4-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(trifluoroethyl)pyridin-2-amine; 1356699-53-0; Boronic acid, B-[2-[[(2,2,2-trifluoroethyl)amino]-4-methyl-5-pyridinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyridin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage under inert atmosphere (argon/nitrogen) is recommended to preserve boronate ester integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.