Description

1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Indoline is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecules for advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and CNS-active compound development.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in next-generation herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport layers.
• Ligand and Catalyst Development: Employed in the synthesis of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged molecules and activity-based probes for target identification and validation in biological systems.
• Academic & Contract Research: A valuable reagent for methodology development and library synthesis in academic and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Indoline
CAS No.	1356699-47-2
Molecular Formula	C20H25BN2O2
Molecular Weight	336.24 g/mol
Synonyms	2-(2-(2,3-Dihydro-1H-indol-1-yl)-4-methylpyridin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-[4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]indoline; 1-(4-Methyl-5-(pinacolatoboryl)pyridin-2-yl)indoline; 5-(Pinacolatoboryl)-2-(2,3-dihydro-1H-indol-1-yl)-4-methylpyridine; 1356699-47-2; Boronic ester pyridine derivative; Indoline-pyridine boronic ester.
EINECS	Contact for details

Quality Control

Our 1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Indoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially air/moisture-sensitive nature. For long-term storage, desiccants are recommended. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.