Description

(3,4)-trans-tert-Butyl 4-Azido-3-Fluoropiperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique piperidine scaffold functionalized with both azido and fluoro groups. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules and targeted therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive azido group for click chemistry and the fluorine atom for modulating pharmacokinetics.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a versatile linker component for constructing bifunctional molecules that target proteins for degradation.
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance metabolic stability and membrane permeability.
• Agrochemical Research: Employed in the development of new active ingredients with improved efficacy and selectivity.
• Chemical Biology Probes: Utilized to create labeled compounds for studying biological pathways and target engagement.

Basic Information

Product Name	(3,4)-trans-tert-Butyl 4-Azido-3-Fluoropiperidine-1-Carboxylate
CAS No.	1356634-02-0
Molecular Formula	C10H17FN4O2
Molecular Weight	244.27 g/mol
Synonyms	tert-Butyl 4-azido-3-fluoropiperidine-1-carboxylate; 1-Boc-4-azido-3-fluoropiperidine; 4-Azido-3-fluoro-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-azido-3-fluoropiperidine; trans-tert-Butyl 4-azido-3-fluoropiperidine-1-carboxylate; (3R,4R)-tert-Butyl 4-azido-3-fluoropiperidine-1-carboxylate (if stereochemistry is defined); 4-N3-3-F-1-Boc-piperidine
EINECS	Contact for details

Quality Control

Our (3,4)-trans-tert-Butyl 4-Azido-3-Fluoropiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of an azido group, handle and store with appropriate safety precautions, avoiding shock, friction, and contact with incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.