Description

3-Fluoropiperidin-4-Ol Hydrochloride is a high-purity, fluorinated piperidine derivative offered as a hydrochloride salt. This compound serves as a critical chiral building block and intermediate in modern synthetic organic chemistry, valued for its ability to introduce both fluorine and hydroxyl functional groups into complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of potential drug candidates, particularly in central nervous system (CNS) and metabolic disease therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Synthesis: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Acts as a monomer or functional additive in the development of specialty polymers with tailored properties.

Basic Information

Product Name	3-Fluoropiperidin-4-Ol Hydrochloride
CAS No.	1356339-27-9
Molecular Formula	C5H11FNO•HCl
Molecular Weight	155.60 (Free base) / 192.02 (HCl salt)
Synonyms	4-Hydroxy-3-fluoropiperidine hydrochloride; 3-Fluoro-4-hydroxypiperidine hydrochloride; 3-Fluoro-4-piperidinol hydrochloride; 3-Fluoropiperidin-4-ol HCl; 4-Piperidinol, 3-fluoro-, hydrochloride; 3-Fluoro-4-hydroxy-piperidine HCl; 3-Fluoro-4-piperidinol HCl salt
EINECS	Contact for details

Quality Control

Our 3-Fluoropiperidin-4-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for advanced research and process chemistry. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.