Description

(5,5-Difluoropiperidin-3-Yl)Methanol Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating new drug candidates, especially in areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its difluorinated piperidine moiety.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the development of protease inhibitors, leveraging the hydrogen-bonding capability of the alcohol group.
• Ligand Synthesis for Drug Discovery: Employed in the creation of sophisticated ligands for various biological targets, where the fluorine atoms can enhance metabolic stability and membrane permeability.
• Fine Chemical Synthesis: Used in multi-step organic syntheses to introduce a functionalized, fluorinated heterocycle into more complex molecular architectures.
• Agrochemical Intermediate: Potential application as an intermediate in the development of advanced agrochemicals with improved efficacy and environmental profiles.

Basic Information

Product Name	(5,5-Difluoropiperidin-3-Yl)Methanol Hydrochloride
CAS No.	1356338-73-2
Molecular Formula	C7H12ClF2NO
Molecular Weight	199.63 g/mol
Synonyms	3-(Hydroxymethyl)-5,5-difluoropiperidine hydrochloride; 5,5-Difluoro-3-piperidinemethanol hydrochloride; (5,5-Difluoropiperidin-3-yl)methanol HCl; 3-Piperidinemethanol, 5,5-difluoro-, hydrochloride; 5,5-Difluoropiperidin-3-ylmethanol hydrochloride; (5,5-Difluoro-3-piperidinyl)methanol hydrochloride
EINECS	Contact for details

Quality Control

Our (5,5-Difluoropiperidin-3-Yl)Methanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.