Description

1-Benzyl 3-Methyl 5,5-Difluoropiperidine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated piperidine core. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its difluoropiperidine scaffold.
• Process Chemistry Development: Serves as a standardized building block for scaling up synthetic routes in API manufacturing.
• Preclinical & Clinical Trial Material Synthesis: Employed in the production of batches for non-clinical and clinical studies.
• Chemical Biology Probes: Utilized in the design of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A starting material for bespoke chemical synthesis services offered to the life sciences industry.

Basic Information

Product Name	1-Benzyl 3-Methyl 5,5-Difluoropiperidine-1,3-Dicarboxylate
CAS No.	1356338-60-7
Molecular Formula	C16H19F2NO4
Molecular Weight	327.33 g/mol
Synonyms	5,5-Difluoropiperidine-1,3-dicarboxylic acid 1-benzyl 3-methyl ester; Benzyl methyl 5,5-difluoropiperidine-1,3-dicarboxylate; 1-Benzyl 3-methyl 5,5-difluoropiperidine-1,3-dicarboxylate; 5,5-Difluoro-1-[(phenylmethoxy)carbonyl]-3-piperidinecarboxylic acid methyl ester; Methyl 1-benzyloxycarbonyl-5,5-difluoropiperidine-3-carboxylate
EINECS	Contact for details

Quality Control

Our 1-Benzyl 3-Methyl 5,5-Difluoropiperidine-1,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider inert atmosphere conditions to preserve optimal quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.