Description

Cyclohexanecarboxylic Acid, 4-Amino-3-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Ethyl Ester, (1R,3S,4S)-Rel- is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a critical building block in the development of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing sophisticated molecular architectures with precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring complex, stereospecific molecules.
• Peptidomimetic Chemistry: Used in the design and construction of peptidomimetics and constrained peptides, where the cyclohexane scaffold provides conformational rigidity.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced, enantiomerically pure agrochemicals such as herbicides and fungicides.
• Catalyst and Ligand Development: Employed as a starting material for synthesizing novel chiral catalysts and ligands used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A valuable starting point for custom synthesis projects and contract research organizations (CROs/CMOs) serving the life sciences sector.

Basic Information

Product Name	Cyclohexanecarboxylic Acid, 4-Amino-3-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Ethyl Ester, (1R,3S,4S)-Rel-
CAS No.	1356337-01-3
Molecular Formula	C15H28N2O4
Molecular Weight	300.40 g/mol
Synonyms	rel-(1R,3S,4S)-Ethyl 4-amino-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate; (1R,3S,4S)-rel-4-Amino-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid ethyl ester; Ethyl 4-amino-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate (rel-(1R,3S,4S)-); 4-Amino-3-Boc-amino-cyclohexanecarboxylic acid ethyl ester (rel-(1R,3S,4S)-); BOC-Protected Cyclohexane Diamino Acid Ester; trans-4-Amino-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylic Acid Ethyl Ester (rel-)
EINECS	Contact for details

Quality Control

Our Cyclohexanecarboxylic Acid, 4-Amino-3-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Ethyl Ester, (1R,3S,4S)-Rel- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric/excess determination and standard pharmacopeial identification tests, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.