Description

tert-Butyl 3-(5-(Trifluoromethyl)pyridin-2-yl)azetidine-1-carboxylate is a high-value, protected azetidine building block featuring a trifluoromethylpyridine moiety, offering unique steric and electronic properties for advanced molecular design. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on creating next-generation therapeutics, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the azetidine scaffold and trifluoromethyl group, improving drug-like properties.
• Agrochemical Development: Serves as a precursor in the research and synthesis of advanced crop protection agents with improved efficacy and environmental profiles.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for catalysis or as a core structure in material science applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 3-(5-(Trifluoromethyl)pyridin-2-yl)azetidine-1-carboxylate
CAS No.	1356109-78-8
Molecular Formula	C14H17F3N2O2
Molecular Weight	302.29 g/mol
Synonyms	1-Boc-3-(5-(trifluoromethyl)pyridin-2-yl)azetidine; tert-Butyl 3-[5-(trifluoromethyl)-2-pyridyl]azetidine-1-carboxylate; 3-(5-(Trifluoromethyl)pyridin-2-yl)azetidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(5-(trifluoromethyl)pyridin-2-yl)azetidine; Azetidine-1-carboxylic acid, 3-[5-(trifluoromethyl)-2-pyridinyl]-, 1,1-dimethylethyl ester; 1356109-78-8; Boc-3-(5-CF3-pyridin-2-yl)azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(5-(Trifluoromethyl)pyridin-2-yl)azetidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports research and development requiring high-purity building blocks for reliable and reproducible results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.