Description

(2R,4R)-2-Amino-4-Pyridin-4-Ylmethyl-Pentanedioic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a chiral glutamic acid backbone substituted with a pyridinylmethyl group. This compound is a critical chiral building block and intermediate in the research and development of novel pharmaceuticals, particularly for creating targeted enzyme inhibitors and receptor modulators. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop new therapeutic agents with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and as a scaffold for designing libraries of bioactive molecules.
• Peptidomimetic Development: Serves as a constrained glutamic acid analog for creating metabolically stable peptide mimics.
• Biochemical Tool Compound: Potential use as a substrate or inhibitor in enzymatic assays and biochemical pathway studies.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective synthetic routes.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(2R,4R)-2-Amino-4-Pyridin-4-Ylmethyl-Pentanedioic Acid
CAS No.	1356090-17-9
Molecular Formula	C12H16N2O4
Molecular Weight	252.27 g/mol
Synonyms	(2R,4R)-2-Amino-4-[(pyridin-4-yl)methyl]pentanedioic acid; (2R,4R)-4-(4-Pyridylmethyl)glutamic acid; (2R,4R)-2-Amino-4-(4-pyridinylmethyl)pentanedioic acid; (2R,4R)-HomoPyGlu; (2R,4R)-2-Amino-4-(pyridin-4-ylmethyl)glutaric acid; (2R,4R)-APG; (2R,4R)-4-Pyridylmethyl-glutamic acid
EINECS	Contact for details

Quality Control

Our (2R,4R)-2-Amino-4-Pyridin-4-Ylmethyl-Pentanedioic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.