Description

3-(2-Methylpyridin-4-Yl)-5-Nitro-1H-Indazole is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic indazole core fused with a methylpyridine substituent. This compound is of significant value in medicinal chemistry for its role as a critical building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the research and development of new chemical entities (NCEs), particularly for targeted therapies.
• Kinase Inhibitor Synthesis: Used as a core scaffold or building block in the synthesis of potential protein kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs within drug discovery pipelines.
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme function and cellular signaling pathways.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis and scale-up projects.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	3-(2-Methylpyridin-4-Yl)-5-Nitro-1H-Indazole
CAS No.	1356088-25-9
Molecular Formula	C13H10N4O2
Molecular Weight	254.24 g/mol
Synonyms	5-Nitro-3-(2-methyl-4-pyridinyl)-1H-indazole; 3-(2-Methyl-4-pyridinyl)-5-nitro-1H-indazole; 1H-Indazole, 3-(2-methyl-4-pyridinyl)-5-nitro-; 3-(2-Methylpyridin-4-yl)-5-nitro-1H-indazole; 5-Nitro-3-(2-methylpyridin-4-yl)-1H-indazole; 3-(2-Methyl-4-pyridyl)-5-nitroindazole
EINECS	Contact for details

Quality Control

Our 3-(2-Methylpyridin-4-Yl)-5-Nitro-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.