Description

2-tert-Butyloxycarbonylamino-3-Methylpyridine-5-Boronic Acid is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in the synthesis of complex molecules, enabling the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for constructing biaryl and heterobiaryl structures central to many bioactive compounds.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the pyridine-boronic acid moiety is a valuable structural component.
• Material Science: Employed in the creation of organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Acts as a tool compound or a handle for bioconjugation in probe and sensor development.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	2-tert-Butyloxycarbonylamino-3-Methylpyridine-5-Boronic Acid
CAS No.	1356087-58-5
Molecular Formula	C12H19BN2O4
Molecular Weight	266.11 g/mol
Synonyms	2-((tert-Butoxycarbonyl)amino)-3-methylpyridine-5-boronic acid; 5-Borono-2-((tert-butoxycarbonyl)amino)-3-methylpyridine; 2-(Boc-amino)-3-methyl-5-pyridineboronic acid; 3-Methyl-2-((tert-butoxycarbonyl)amino)pyridine-5-boronic acid; Boc-2-Amino-3-methyl-5-pyridineboronic Acid; 2-tert-Butoxycarbonylamino-3-methylpyridine-5-boronic acid; 2-(N-Boc-amino)-3-methyl-5-pyridinylboronic acid
EINECS	Contact for details

Quality Control

Our 2-tert-Butyloxycarbonylamino-3-Methylpyridine-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements of research and production applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.