Description

tert-Butyl 8-Methyl-3-Nitro-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the naphthyridine class of heterocyclic compounds. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents, where precise molecular construction is critical.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities with improved efficacy and safety profiles.
• API Synthesis: A key building block for constructing complex molecular architectures found in investigational new drugs, leveraging its naphthyridine core and functional groups for further chemical modifications.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and developing new synthetic methodologies.

Basic Information

Product Name	tert-Butyl 8-Methyl-3-Nitro-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate
CAS No.	1356087-16-5
Molecular Formula	C15H19N3O4
Molecular Weight	305.33 g/mol
Synonyms	6-Boc-8-methyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine; tert-Butyl 8-methyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate; 8-Methyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylic acid tert-butyl ester; 1,6-Naphthyridine-6(5H)-carboxylic acid, 7,8-dihydro-8-methyl-3-nitro-, 1,1-dimethylethyl ester; 1356087-16-5; Boc-protected nitro-tetrahydro-naphthyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Methyl-3-Nitro-7,8-Dihydro-1,6-Naphthyridine-6(5H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and stored away from direct light and moisture to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.