Description

1,1-Difluoro-3-isocyanocyclobutane CAS NO 1355328-31-2 is a versatile and highly reactive fluorinated isocyanate building block. Its unique cyclobutane core and difluoro substitution pattern make it a valuable intermediate for introducing structural complexity and fluorine atoms into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent for the production of specialty polymers, coatings, and resins with unique thermal and chemical resistance properties.
• Fluorine Chemistry Research: A critical reagent for exploring new reactions and methodologies in organofluorine chemistry and cyclobutane ring systems.
• Peptide Mimetics & Bio-conjugation: The reactive isocyanate group enables efficient coupling with amines and alcohols for creating peptide analogs or functionalizing biomolecules.
• Ligand & Catalyst Development: Employed in the synthesis of novel ligands and organocatalysts for asymmetric synthesis and transition metal catalysis.

Basic Information

Product Name	1,1-Difluoro-3-isocyanocyclobutane
CAS No.	1355328-31-2
Molecular Formula	C5H5F2NO
Molecular Weight	133.10 g/mol
Synonyms	3-Isocyanato-1,1-difluorocyclobutane; 1,1-Difluorocyclobutane-3-isocyanate; Difluorocyclobutyl isocyanate; Cyclobutane, 1,1-difluoro-3-isocyanato-; 1355328-31-2
EINECS	Contact for details

Quality Control

Our 1,1-Difluoro-3-isocyanocyclobutane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at recommended temperatures (typically 2-8°C or as specified on the label). Due to its hygroscopic and highly volatile nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.