Description

2-Chloro-5-Fluoro-Thiazolo[5,4-B]Pyridine (CAS NO 1355241-45-0) is a high-purity, advanced pharmaceutical intermediate belonging to the fused heterocyclic compound class. This compound is of significant commercial interest due to its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral research. It is primarily sought after by R&D laboratories, process development chemists, and manufacturers within the pharmaceutical and agrochemical industries for developing next-generation therapeutics.

Application

This specialized intermediate serves as a key precursor in various sophisticated chemical syntheses. Its primary applications include:

• Pharmaceutical Intermediate: A crucial scaffold for the research and development of new drug candidates, especially in kinase inhibitor programs for cancer treatment.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides, leveraging its unique heterocyclic structure for biological activity.
• Material Science Research: Acts as a building block for organic electronic materials and ligands in catalytic systems due to its electron-deficient aromatic system.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process optimization for client projects.
• Academic Research: Utilized in universities and research institutes for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	2-Chloro-5-Fluoro-Thiazolo[5,4-B]Pyridine
CAS No.	1355241-45-0
Molecular Formula	C6HClFN2S
Molecular Weight	188.60 g/mol
Synonyms	2-Chloro-5-fluorothiazolo[5,4-b]pyridine; Thiazolo[5,4-b]pyridine, 2-chloro-5-fluoro-; 1355241-45-0; 2-Chloro-5-fluoro-[1,3]thiazolo[5,4-b]pyridine; 5-Fluoro-2-chlorothiazolo[5,4-b]pyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-Thiazolo[5,4-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.