Description

tert-Butyl 3,3-Difluorocyclobutanecarboxylate is a high-value fluorinated cyclobutane building block, essential for introducing conformational rigidity and fluorine atoms into complex molecular architectures. Its primary commercial value lies in serving as a key intermediate in the synthesis of advanced pharmaceutical compounds and agrochemicals, where the cyclobutane and difluoro motifs are critical for modulating biological activity and metabolic stability. This product is specifically targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable intermediates for their synthetic campaigns.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, protease inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorinated cyclobutane ring can enhance potency and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials that benefit from the unique electronic properties of fluorine.
• Chemical Biology Probes: Utilized to synthesize fluorinated analogs of natural products or biological molecules for use as probes in mechanistic and metabolic studies.

Basic Information

Product Name	tert-Butyl 3,3-Difluorocyclobutanecarboxylate
CAS No.	1355070-36-8
Molecular Formula	C9H14F2O2
Molecular Weight	192.20 g/mol
Synonyms	3,3-Difluorocyclobutanecarboxylic acid tert-butyl ester; tert-Butyl 3,3-difluorocyclobutane-1-carboxylate; 1-(tert-Butoxycarbonyl)-3,3-difluorocyclobutane; 3,3-Difluorocyclobutanecarboxylic acid 1,1-dimethylethyl ester; TBDFCB; BOC-3,3-Difluorocyclobutane
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,3-Difluorocyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.