Description

5-Azido Uridine is a modified nucleoside analog, a critical building block in chemical biology and pharmaceutical research. Its unique azido functional group enables bioorthogonal click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC), for precise labeling and conjugation of biomolecules. This compound is essential for researchers and manufacturers in the fields of oligonucleotide synthesis, prodrug development, and the creation of diagnostic probes and targeted therapeutics.

Application

• Click Chemistry Reagent: Serves as a key substrate for CuAAC and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions to label nucleic acids.
• Oligonucleotide Synthesis: Used in the solid-phase synthesis of modified RNA and DNA strands for research and therapeutic applications.
• Prodrug Development: Incorporated into nucleoside analog prodrugs to enhance targeting and controlled release mechanisms.
• Bioconjugation: Facilitates the site-specific attachment of fluorophores, affinity tags, or drug molecules to uridine-containing biomolecules.
• Chemical Biology Probes: Enables the study of RNA metabolism, localization, and protein-RNA interactions through metabolic incorporation and subsequent labeling.
• Antiviral Research: Investigated as a precursor for novel nucleoside analogs with potential antiviral activity.

Basic Information

Product Name	5-Azido Uridine
CAS No.	1355028-82-8
Molecular Formula	C9H11N5O6
Molecular Weight	285.22 g/mol
Synonyms	5-Azidouridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-azidopyrimidine-2,4(1H,3H)-dione; 5-Azido-1-β-D-ribofuranosyluracil; 5-N3-Uridine; Azido Uridine
EINECS	Contact for details

Quality Control

Every batch of 5-Azido Uridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.