Description

1-Methylhexahydro-1H-Imidazo[4,5-C]Pyridin-2(3H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the imidazopyridine class of heterocyclic compounds. This compound is of significant commercial interest due to its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in neurological and psychiatric therapeutic areas. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potent drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing novel chemical libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Synthesis: Integral in the development and scale-up of production processes for new chemical entities (NCEs), especially those with imidazopyridine-based pharmacophores.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays to study specific enzyme or receptor interactions.

Basic Information

Product Name	1-Methylhexahydro-1H-Imidazo[4,5-C]Pyridin-2(3H)-One
CAS No.	1355004-58-8
Molecular Formula	C8H13N3O
Molecular Weight	167.21 g/mol
Synonyms	1-Methyl-1,4,5,6,7,8-hexahydroimidazo[4,5-c]pyridin-2(3H)-one; 1-Methyl-2,3,4,5,6,7-hexahydro-1H-imidazo[4,5-c]pyridin-2-one; 1-Methyl-1,4,5,6,7,8-hexahydro-2H-imidazo[4,5-c]pyridin-2-one; Imidazo[4,5-c]pyridin-2(3H)-one, 1-methyl-1,4,5,6,7,8-hexahydro-; 1355004-58-8
EINECS	Contact for details

Quality Control

Our 1-Methylhexahydro-1H-Imidazo[4,5-C]Pyridin-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production can adhere to cGMP guidelines for pharmaceutical intermediates, ensuring supply reliability and regulatory compliance for critical development and manufacturing projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider holding under an inert atmosphere to maintain optimal stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.