Description

tert-Butyl 5-Chloro-2,4-Difluorobenzoate is a high-purity, synthetically valuable benzoate ester derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. It is primarily required by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorobenzene and chlorobenzene motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its halogenated aromatic structure.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic processes and material science.
• Organic Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and other transformations to introduce functionalized benzoate groups.
• Material Science Research: Utilized in the development of organic electronic materials, liquid crystals, and polymers.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 5-Chloro-2,4-Difluorobenzoate
CAS No.	1354961-13-9
Molecular Formula	C11H11ClF2O2
Molecular Weight	248.65 g/mol
Synonyms	5-Chloro-2,4-difluorobenzoic acid tert-butyl ester; tert-Butyl 5-chloro-2,4-difluorobenzoate; Benzoic acid, 5-chloro-2,4-difluoro-, 1,1-dimethylethyl ester; 2,4-Difluoro-5-chlorobenzoic acid tert-butyl ester; 1,1-Dimethylethyl 5-chloro-2,4-difluorobenzoate; t-Butyl 5-chloro-2,4-difluorobenzoate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Chloro-2,4-Difluorobenzoate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.