Description

6,6-Difluorospiro[3.3]heptan-2-amine hydrochloride is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing next-generation therapeutics, particularly in areas like kinase inhibitors and central nervous system (CNS) agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting protein kinases.
• Medicinal Chemistry Research: Used to introduce the rigid, three-dimensional spiro[3.3]heptane core and fluorine atoms into lead compounds to optimize their potency, selectivity, and pharmacokinetic properties.
• Bioconjugation & Probe Development: The amine hydrochloride salt serves as a handle for conjugation in the development of chemical probes and labeled compounds for biological studies.
• Agrochemical Research: Potential intermediate in the research and development of new crop protection agents with improved efficacy.
• Material Science: Exploration of applications in advanced materials, leveraging its unique fluorine-containing spirocyclic structure.

Basic Information

Product Name	6,6-Difluorospiro[3.3]heptan-2-amine hydrochloride
CAS No.	1354952-13-8
Molecular Formula	C7H10ClF2N
Molecular Weight	181.61 g/mol
Synonyms	6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride; 2-Amino-6,6-difluorospiro[3.3]heptane hydrochloride; 6,6-Difluorospiro[3.3]heptan-2-amine HCl; 6,6-Difluoro-2-azaspiro[3.3]heptane HCl; 1354952-13-8; 6,6-Difluoro-2-azaspiro[3.3]heptane, hydrochloride; 2-Amino-6,6-difluorospiro[3.3]heptane HCl
EINECS	Contact for details

Quality Control

Our 6,6-Difluorospiro[3.3]heptan-2-amine hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support our partners with full traceability and documentation to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.