Description

Leniolisib is a potent and selective small-molecule inhibitor of the delta isoform of phosphoinositide 3-kinase (PI3Kδ). This compound is of significant interest for its targeted mechanism of action in modulating immune cell signaling pathways. It is primarily utilized in pharmaceutical research and development for the creation of novel therapeutics targeting specific immune dysregulation conditions.

Application

• Pharmaceutical Active Ingredient (API): Serves as the key active component in the formulation of investigational and approved drug products.
• Immunology Research: A critical tool for studying PI3Kδ signaling pathways in B-cells, T-cells, and other immune cells in preclinical models.
• Oncology Research: Investigated for its potential role in targeting hematological malignancies driven by aberrant PI3Kδ activity.
• Reference Standard: Used as a high-purity analytical standard for quality control, method development, and regulatory submissions.
• Process Chemistry & Scale-up: Employed in the development and optimization of synthetic routes for commercial manufacturing.
• Drug Discovery & Development: A lead compound for the design and synthesis of novel PI3Kδ inhibitors with improved pharmacokinetic profiles.

Basic Information

Product Name	Leniolisib
CAS No.	1354690-24-6
Molecular Formula	C22H23N5O2
Molecular Weight	389.45 g/mol
Synonyms	CDZ173; 5-((2S)-2-((1H-Pyrazolo[3,4-d]pyrimidin-4-yl)amino)-3-piperidin-1-ylpropyl)quinolin-8-ol; PI3Kδ Inhibitor CDZ173; (2S)-2-[(1H-Pyrazolo[3,4-d]pyrimidin-4-yl)amino]-3-(1-piperidinyl)propyl-8-quinolinol; JNJ-64264681
EINECS	Contact for details

Quality Control

Our Leniolisib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities to ensure compliance with pharmaceutical-grade standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.