Description

Tco/E- Active Ester (p-Npe) / Equatorial is a specialized, high-purity chemical intermediate designed for advanced bioconjugation and peptide synthesis. This compound matters for its role as a key building block in the development of pharmaceuticals, particularly in the creation of antibody-drug conjugates (ADCs) and other targeted therapeutics. It is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in cutting-edge drug discovery and development.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: A critical component for constructing cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Peptide and Protein Modification: Used for site-specific labeling and functionalization of biomolecules under mild aqueous conditions.
• Solid-Phase Peptide Synthesis (SPPS): Serves as an activated ester for efficient coupling of amino acids, especially for sterically hindered sequences.
• Prodrug Development: Employed in designing prodrugs with triggered release mechanisms for enhanced therapeutic efficacy and reduced side effects.
• Biomaterial Functionalization: Enables the covalent attachment of bioactive peptides to polymer surfaces, hydrogels, and medical devices.
• Diagnostic Reagent Preparation: Used in the synthesis of fluorescent or radioactive probes for imaging and diagnostic assays.

Basic Information

Product Name	Tco/E- Active Ester (p-Npe) / Equatorial
CAS No.	1354323-64-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	trans-Cyclooctene p-Nitrophenyl Ester (Equatorial); TCO-PNP ester; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (4-nitrophenyl) carbonate; Equatorial TCO-NPC; TCO active ester; TCO-PNP; TCO-NPC; Bicyclo[6.1.0]non-4-yn-9-ylmethyl 4-nitrophenyl carbonate (Equatorial isomer)
EINECS	Contact for details

Quality Control

Our Tco/E- Active Ester (p-Npe) / Equatorial is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, isomer content, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isomeric Purity (Equatorial)	≥ 98%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.