Description

Methyl 4-Bromo-1-Methyl-2-Naphthoate CAS NO 1354035-48-5 is a high-purity, functionalized naphthoate ester derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic positioning of the bromine substituent, which enables selective cross-coupling reactions for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, leveraging its halogenated naphthalene core for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form carbon-carbon and carbon-heteroatom bonds.
• Chemical Synthesis Reference Standard: Used as a certified reference material (CRM) for analytical method development and quality control in chemical manufacturing.
• Academic & R&D Laboratories: Fundamental reagent for methodological studies in organic synthesis and catalysis research at universities and corporate R&D centers.

Basic Information

Product Name	Methyl 4-Bromo-1-Methyl-2-Naphthoate
CAS No.	1354035-48-5
Molecular Formula	C₁₃H₁₁BrO₂
Molecular Weight	279.13 g/mol
Synonyms	4-Bromo-1-methyl-2-naphthoic acid methyl ester; Methyl 4-bromo-1-methyl-2-naphthalenecarboxylate; 2-Naphthalenecarboxylic acid, 4-bromo-1-methyl-, methyl ester; 1-Methyl-4-bromo-2-naphthoic acid methyl ester; 4-Bromo-1-methylnaphthalene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-Bromo-1-Methyl-2-Naphthoate is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade meets stringent in-house specifications, with purity typically ≥97% (by HPLC). A detailed Certificate of Analysis (COA) providing results for assay, related substances, and residual solvents is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is stable under inert atmosphere. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.