Description

(R)-3-(6-Ethoxy-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the development of novel, enantiomerically pure active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise stereochemistry. This compound is essential for research and development chemists, process scale-up teams, and manufacturers in the global pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of enantiomerically pure drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key building block in the research and process chemistry for new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized in medicinal chemistry for constructing complex molecular architectures with defined stereocenters.
• Contract Manufacturing & Research (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of pharmaceutical compounds.
• Process Chemistry & Optimization: Used in route scouting and optimization studies for more efficient and cost-effective API manufacturing processes.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory filings (e.g., FDA, EMA).

Basic Information

Product Name	(R)-3-(6-Ethoxy-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354020-91-9
Molecular Formula	C15H24N4O3
Molecular Weight	308.38 g/mol
Synonyms	tert-Butyl (3R)-3-[(6-ethoxypyrimidin-4-yl)amino]pyrrolidine-1-carboxylate; (R)-tert-Butyl 3-((6-ethoxypyrimidin-4-yl)amino)pyrrolidine-1-carboxylate; 1-BOC-3R-[(6-ethoxy-4-pyrimidinyl)amino]pyrrolidine; Boc-(R)-3-((6-ethoxypyrimidin-4-yl)amino)pyrrolidine; (R)-1-Boc-3-((6-ethoxypyrimidin-4-yl)amino)pyrrolidine; 1354020-91-9; (S)-Enantiomer of related pyrrolidine intermediates.
EINECS	Contact for details

Quality Control

Our production of (R)-3-(6-Ethoxy-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems, ensuring batch-to-batch consistency and high chemical purity. Each lot is fully characterized and tested against rigorous in-house specifications, which typically include chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.