Description

(S)-3-(2-Methoxy-Phenylsulfanyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a key synthon for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) with high efficacy and specificity. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Used as a key starting material or intermediate in stereoselective synthesis to introduce the (S)-configured pyrrolidine scaffold into target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for discovering new bioactive compounds.
• Process Chemistry Development: Serves as a scalable intermediate for the development and optimization of commercial manufacturing routes for APIs.
• Agrochemical Synthesis: Potential use as an intermediate in the production of chiral agrochemicals, such as herbicides or fungicides, where stereochemistry affects biological activity.
• Catalyst and Ligand Preparation: Can be utilized in the synthesis of novel chiral catalysts or ligands for asymmetric catalysis.

Basic Information

Product Name	(S)-3-(2-Methoxy-Phenylsulfanyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354006-79-3
Molecular Formula	C16H23NO3S
Molecular Weight	309.42 g/mol
Synonyms	tert-Butyl (3S)-3-[(2-methoxyphenyl)sulfanyl]pyrrolidine-1-carboxylate; (S)-1-Boc-3-((2-methoxyphenyl)thio)pyrrolidine; (S)-3-(2-Methoxyphenylthio)-1-Boc-pyrrolidine; 1-Boc-3-[(2-methoxyphenyl)thio]-(S)-pyrrolidine; (S)-1-(tert-Butoxycarbonyl)-3-[(2-methoxyphenyl)thio]pyrrolidine; (S)-3-(2-Methoxyphenylsulfanyl)pyrrolidine-1-carboxylic acid tert-butyl ester; (S)-N-Boc-3-(2-methoxyphenylthio)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-3-(2-Methoxy-Phenylsulfanyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.