Description

(R)-3-(2-Chloro-Acetylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic utility. Its core value lies in its role as a key precursor for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and bioactive compounds. This compound is essential for research and manufacturing organizations in the pharmaceutical, biotechnology, and fine chemical sectors, where precise stereochemistry and reliable quality are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in therapeutic areas requiring pyrrolidine-based scaffolds.
• Protease Inhibitor Synthesis: Serves as a key building block in the synthesis of protease inhibitors, which are vital for treatments targeting viral infections and certain cancers.
• Peptidomimetic Chemistry: Used in the design and construction of peptidomimetics, which are molecules that mimic peptides but with enhanced stability and bioavailability for drug discovery.
• Asymmetric Synthesis: Employed in asymmetric catalytic reactions and multi-step synthetic routes to introduce the (R)-configured pyrrolidine moiety with high enantiomeric purity.
• Medicinal Chemistry Research: A valuable tool for medicinal chemists in structure-activity relationship (SAR) studies and lead optimization programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	(R)-3-(2-Chloro-Acetylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353998-17-0
Molecular Formula	C11H19ClN2O3
Molecular Weight	262.73 g/mol
Synonyms	(R)-1-Boc-3-(2-chloroacetamido)pyrrolidine; tert-Butyl (3R)-3-[(2-chloroacetyl)amino]pyrrolidine-1-carboxylate; (R)-1-N-Boc-3-(2-chloroacetamido)pyrrolidine; (3R)-1-(tert-Butoxycarbonyl)-3-[(2-chloroacetyl)amino]pyrrolidine; (R)-3-(Chloroacetamido)pyrrolidine-1-carboxylic acid tert-butyl ester; Boc-(R)-3-Aminopyrrolidine chloroacetamide derivative; (R)-N-Boc-3-amino-N-(2-chloroacetyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-3-(2-Chloro-Acetylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC, chiral analysis, and NMR, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each batch. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.