Description

Toluene-4-Sulfonic Acid (S)-1-Acetyl-Pyrrolidin-2-Ylmethyl Ester is a specialized chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its core value proposition lies in its role as a protected or activated form of a key chiral pyrrolidine motif, enabling the stereoselective construction of complex molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require high-purity, enantiomerically pure intermediates for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in classes like protease inhibitors, neurological agents, and other small-molecule therapeutics.
• Asymmetric Synthesis: Used as a chiral auxiliary or a protected chiral amine equivalent in stereocontrolled carbon-carbon and carbon-heteroatom bond-forming reactions.
• Agrochemical Research: Serves as a building block for creating enantiomerically pure compounds with potential herbicidal, fungicidal, or insecticidal activity.
• Catalyst Ligand Precursor: Can be utilized in the synthesis of chiral ligands for asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Peptidomimetics & Bioactive Molecule Design: The acetyl-pyrrolidine structure is a common scaffold in drug design, making this ester a valuable precursor for peptidomimetic compounds and other bioactive molecules.

Basic Information

Product Name	Toluene-4-Sulfonic Acid (S)-1-Acetyl-Pyrrolidin-2-Ylmethyl Ester
CAS No.	1353994-74-7
Molecular Formula	C15H21NO4S
Molecular Weight	311.40 g/mol
Synonyms	(S)-1-Acetyl-2-((tosyloxy)methyl)pyrrolidine; (S)-1-Acetyl-2-((p-toluenesulfonyloxy)methyl)pyrrolidine; (S)-2-((p-Toluenesulfonyloxy)methyl)-1-acetylpyrrolidine; (S)-1-Acetyl-2-((4-methylphenyl)sulfonyloxy)methyl)pyrrolidine; (S)-Tosyloxymethyl-1-acetylpyrrolidine; (S)-1-Acetyl-2-(tosyloxymethyl)pyrrolidine; (S)-N-Acetyl-2-(p-toluenesulfonyloxymethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our production of Toluene-4-Sulfonic Acid (S)-1-Acetyl-Pyrrolidin-2-Ylmethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and purity assessment. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.