Description

3-[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a sophisticated, high-purity chemical intermediate designed for advanced synthesis. This compound is critical for research and development in pharmaceutical chemistry, serving as a key building block for constructing complex molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a key starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Agrochemical Synthesis: Employed in the research and development of novel pesticides and herbicides, leveraging its heterocyclic scaffold.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized compounds for clients.
• Academic Research: Used in university and institutional laboratories for methodological development and exploring new chemical transformations involving amide and ester functionalities.

Basic Information

Product Name	3-[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353989-82-8
Molecular Formula	C15H20ClN3O3
Molecular Weight	325.79 g/mol
Synonyms	tert-Butyl 3-[(2-chloropyridine-3-carbonyl)amino]pyrrolidine-1-carboxylate; 1-Boc-3-[(2-chloronicotinoyl)amino]pyrrolidine; (2-Chloro-pyridine-3-carbonyl)-pyrrolidin-3-yl-amine tert-butyl ester; 3-[(2-Chloronicotinoyl)amino]-1-(tert-butoxycarbonyl)pyrrolidine; 1-N-Boc-3-[(2-chloronicotinoyl)amino]pyrrolidine; 3-Amino-1-Boc-pyrrolidine-2-chloronicotinamide; Pyrrolidine, 3-[(2-chloro-3-pyridinyl)carbonyl]amino]-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Every batch of 3-[(2-Chloro-Pyridine-3-Carbonyl)-Amino]-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support development and commercial projects requiring material that meets GMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with all applicable regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Related Substances (HPLC)	Any single impurity ≤1.0%; Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.