Description

Toluene-4-Sulfonic Acid 1-Acetyl-Pyrrolidin-3-Ylmethyl Ester CAS NO 1353979-05-1 is a specialized organic synthetic intermediate, primarily valued for its role as a versatile building block in advanced pharmaceutical and agrochemical research. Its molecular structure, featuring both a sulfonate ester and an acetylated pyrrolidine moiety, makes it a critical reagent for introducing specific functional groups and protecting groups in complex synthesis pathways. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs) and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its sulfonate ester group for structural modification.
• Peptide Chemistry: Serves as a reagent or protecting group agent in the synthesis of modified peptides and peptidomimetics.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for commercial production of fine chemicals.

Basic Information

Product Name	Toluene-4-Sulfonic Acid 1-Acetyl-Pyrrolidin-3-Ylmethyl Ester
CAS No.	1353979-05-1
Molecular Formula	C15H21NO4S
Molecular Weight	311.40 g/mol
Synonyms	1-Acetyl-3-((tosyloxy)methyl)pyrrolidine; 1-Acetyl-3-(p-toluenesulfonyloxymethyl)pyrrolidine; 3-((4-Methylphenyl)sulfonyloxymethyl)-1-pyrrolidinecarboxylic acid ethyl ester (related); Tosyloxyacetyl pyrrolidine derivative; p-Toluenesulfonic acid 1-acetyl-3-pyrrolidinylmethyl ester; 1-Acetyl-3-(p-tolylsulfonyloxymethyl)azolidine; (1-Acetylpyrrolidin-3-yl)methyl 4-methylbenzenesulfonate
EINECS	Contact for details

Quality Control

Our Toluene-4-Sulfonic Acid 1-Acetyl-Pyrrolidin-3-Ylmethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.