Description

C-[1-(Pyridine-2-Sulfonyl)-Piperidin-4-Yl]-Methylamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block of significant importance in modern organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific enzymes, leveraging the pyridine-sulfonyl-piperidine scaffold.
• Kinase Inhibitor Synthesis: Serves as a core structural component in the creation of potential kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.
• Academic Research: Utilized in university and institutional labs for methodological development and exploring new chemical spaces.

Basic Information

Product Name	C-[1-(Pyridine-2-Sulfonyl)-Piperidin-4-Yl]-Methylamine Hydrochloride
CAS No.	1353978-68-3
Molecular Formula	C12H19N3O2S • HCl
Molecular Weight	305.82 g/mol (Free base: 269.36 g/mol)
Synonyms	1-(Pyridin-2-ylsulfonyl)piperidin-4-ylmethanamine hydrochloride; 4-(Aminomethyl)-1-(pyridine-2-sulfonyl)piperidine hydrochloride; (1-(Pyridine-2-sulfonyl)piperidin-4-yl)methanamine HCl; C-[1-(2-Pyridylsulfonyl)-4-piperidyl]methylamine hydrochloride; 1-(Pyridin-2-ylsulfonyl)-4-piperidinemethanamine hydrochloride; 4-(Aminomethyl)-1-(2-pyridinesulfonyl)piperidine hydrochloride; CAS 1353978-68-3
EINECS	Contact for details

Quality Control

Our C-[1-(Pyridine-2-Sulfonyl)-Piperidin-4-Yl]-Methylamine Hydrochloride is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.