Description

(4-Iodo-Cyclohexyl)-Carbamic Acid Benzyl Ester is a specialized organic building block featuring a carbamate-protected amine and an iodine substituent on a cyclohexane ring. This unique bifunctional structure makes it a valuable intermediate for the synthesis of complex molecules in pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists seeking to introduce a protected amine handle and a versatile iodine functional group for further cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders or metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the iodine atom allows for further structural diversification.
• Peptidomimetics & PROTACs: The carbamate-protected cyclohexylamine moiety is valuable for constructing non-peptide scaffolds and linkers in proteolysis-targeting chimera (PROTAC) drug discovery.
• Material Science: Acts as a monomer or cross-linking agent in the research of advanced polymers with specific thermal or mechanical properties.
• Chemical Biology Probes: Utilized to create labeled compounds or affinity probes for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The aryl iodide functionality is pivotal for metal-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, or Buchwald-Hartwig amination, to build complex molecular architectures.

Basic Information

Product Name	(4-Iodo-Cyclohexyl)-Carbamic Acid Benzyl Ester
CAS No.	1353970-61-2
Molecular Formula	C14H18INO2
Molecular Weight	359.20 g/mol
Synonyms	Benzyl (4-iodocyclohexyl)carbamate; N-(Benzyloxycarbonyl)-4-iodocyclohexylamine; 4-Iodo-N-Cbz-cyclohexylamine; 4-Iodocyclohexylcarbamic Acid Benzyl Ester; Carbamic acid, N-(4-iodocyclohexyl)-, phenylmethyl ester; Z-4-Iodocyclohexylamine; Cbz-4-Iodocyclohexylamine; (4-Iodocyclohexyl)carbamic Acid Phenylmethyl Ester
EINECS	Contact for details

Quality Control

Our (4-Iodo-Cyclohexyl)-Carbamic Acid Benzyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your research and development needs with reliable, high-purity intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.