Description

4-(Pyridin-4-Ylsulfanylmethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group and a pyridinylthioether side chain. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential biological activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel drug candidates, particularly in areas targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its modifiable functional groups.
• Protease Inhibitor Scaffolds: The piperidine-Boc structure is common in the development of protease and kinase inhibitor libraries.
• Ligand Synthesis for Catalysis: Can be utilized to create specialized ligands for asymmetric catalysis and metal-organic frameworks.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and cellular pathways.
• Peptidomimetic Chemistry: Serves as a constrained scaffold in the design of peptidomimetics to enhance metabolic stability and bioavailability.

Basic Information

Product Name	4-(Pyridin-4-Ylsulfanylmethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353967-26-6
Molecular Formula	C16H24N2O2S
Molecular Weight	308.44 g/mol
Synonyms	1-Boc-4-[(pyridin-4-ylthio)methyl]piperidine; 4-[(1-Boc-4-piperidinyl)methyl]thio]pyridine; tert-Butyl 4-[(pyridin-4-ylsulfanyl)methyl]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(4-pyridinylthio)methyl]piperidine; 4-(Pyridin-4-ylthiomethyl)piperidine-1-carboxylic acid tert-butyl ester; 4-Pyridylthiomethylpiperidine-1-Boc; Boc-4-(4-Pyridylthiomethyl)piperidine
EINECS	Contact for details

Quality Control

Our 4-(Pyridin-4-Ylsulfanylmethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.