Description

(4-Amino-Piperidin-1-Yl)-(2,3-Dihydro-Benzo[1,4]Dioxin-5-Yl)-Methanone Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1353951-55-9. This compound is a critical building block in modern medicinal chemistry, valued for its piperidine and benzodioxane structural motifs which are prevalent in active pharmaceutical ingredients. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and cardiovascular drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Employed in the synthesis of potential therapeutics targeting neurological disorders, leveraging the piperidine moiety.
• Cardiovascular Agent Synthesis: Serves as a building block for compounds being investigated for cardiovascular applications.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for pharmacological studies and novel synthetic route exploration.

Basic Information

Product Name	(4-Amino-Piperidin-1-Yl)-(2,3-Dihydro-Benzo[1,4]Dioxin-5-Yl)-Methanone Hydrochloride
CAS No.	1353951-55-9
Molecular Formula	C15H19N2O3·HCl
Molecular Weight	308.79 g/mol (Free base: 275.33 g/mol)
Synonyms	5-[(4-Aminopiperidin-1-yl)carbonyl]-2,3-dihydro-1,4-benzodioxine hydrochloride; 1,4-Benzodioxin-5-yl(4-aminopiperidin-1-yl)methanone hydrochloride; (4-Aminopiperidin-1-yl)(2,3-dihydro-1,4-benzodioxin-5-yl)methanone HCl; CAS 1353951-55-9; 1353951-55-9; Benzodioxinyl piperidinyl methanone hydrochloride derivative.
EINECS	Contact for details

Quality Control

Our (4-Amino-Piperidin-1-Yl)-(2,3-Dihydro-Benzo[1,4]Dioxin-5-Yl)-Methanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.