Description

2-(4-Chloro-Benzenesulfonylmethyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a pyrrolidine scaffold with a sulfonylmethyl linker. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting protease and kinase inhibition. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Protease Inhibitor Development: Used in research for creating novel inhibitors due to its sulfonamide and pyrrolidine functional groups.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study enzyme function and signaling pathways.
• Peptidomimetic Synthesis: Employed in the design and synthesis of peptidomimetics to improve metabolic stability and bioavailability.
• Library Synthesis for HTS: A valuable starting material for generating diverse compound libraries for high-throughput screening (HTS) campaigns.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-(4-Chloro-Benzenesulfonylmethyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353945-74-0
Molecular Formula	C₁₆H₂₂ClNO₄S
Molecular Weight	359.87 g/mol
Synonyms	tert-Butyl 2-[(4-chlorophenyl)sulfonylmethyl]pyrrolidine-1-carboxylate; 1-Boc-2-((4-chlorophenyl)sulfonylmethyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-2-((4-chlorophenyl)sulfonylmethyl)pyrrolidine; 2-((4-Chlorophenyl)sulfonylmethyl)-1-(tert-butoxycarbonyl)pyrrolidine; N-Boc-2-((4-chlorophenyl)sulfonylmethyl)pyrrolidine; Pyrrolidine-1-carboxylic acid, 2-[(4-chlorophenyl)sulfonylmethyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Chloro-Benzenesulfonylmethyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity for demanding research applications. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.