Description

tert-Butyl(1R,2S,5S)-2-Azido-5-[(Dimethylamino)Carbonyl]Cyclohexylcarbamate Oxalic Acid is a high-purity, chiral organic salt primarily used as a sophisticated synthetic intermediate in pharmaceutical research and development. This compound matters because it provides a critical, stereochemically defined building block for constructing complex active pharmaceutical ingredients (APIs), particularly in antiviral and protease inhibitor drug discovery programs. Pharmaceutical companies, contract research organizations (CROs), and advanced fine chemical manufacturers need this material for its role in enabling the synthesis of novel therapeutic candidates with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly protease inhibitors and antiviral agents.
• Peptidomimetic Research: Used to introduce constrained cyclohexyl scaffolds and azide functional groups into peptide backbones for creating stable, bioactive analogs.
• Chemical Biology & Probe Development: The azide moiety enables click chemistry applications (e.g., CuAAC) for bioconjugation and labeling studies in target identification.
• Asymmetric Synthesis: Serves as a starting material or intermediate for constructing other enantiomerically pure compounds due to its defined (1R,2S,5S) stereochemistry.
• Process Chemistry & Scale-Up: Employed in route development and optimization for the commercial-scale production of candidate drugs.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and medicinal chemistry projects.

Basic Information

Product Name	tert-Butyl(1R,2S,5S)-2-Azido-5-[(Dimethylamino)Carbonyl]Cyclohexylcarbamate Oxalic Acid
CAS No.	1353893-22-7
Molecular Formula	C16H27N5O5 • C2H2O4
Molecular Weight	487.46 g/mol
Synonyms	(1R,2S,5S)-2-Azido-5-[(dimethylamino)carbonyl]cyclohexyl tert-butylcarbamate oxalate; tert-Butyl N-[(1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl]carbamate oxalic acid salt; (1R,2S,5S)-2-Azido-5-(dimethylcarbamoyl)cyclohexyl carbamic acid tert-butyl ester oxalate; Boc-Protected Azido Cyclohexyl Carboxamide Oxalate; (S,S,R)-Boc-AADC-Oxalate; CAS 1353893-22-7; Pharmaceutical Intermediate 1353893-22-7
EINECS	Contact for details

Quality Control

Our production of tert-Butyl(1R,2S,5S)-2-Azido-5-[(Dimethylamino)Carbonyl]Cyclohexylcarbamate Oxalic Acid adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.