Description

4-Iodo-2-Isopropoxypyridine is a high-purity halogenated pyridine derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in its unique reactivity, where the iodine atom serves as an excellent handle for cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen functionality for structural diversification.
• Material Science Precursor: Serves as a building block for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed reactions such as Suzuki-Miyaura, Stille, and Negishi couplings to form new carbon-carbon bonds.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.
• Ligand Modification: Useful for the functionalization of complex molecules and catalysts in coordination chemistry.

Basic Information

Product Name	4-Iodo-2-Isopropoxypyridine
CAS No.	1353777-52-2
Molecular Formula	C8H10INO
Molecular Weight	263.08 g/mol
Synonyms	2-Isopropoxy-4-iodopyridine; 4-Iodo-2-(1-methylethoxy)pyridine; 4-Iodo-2-(propan-2-yloxy)pyridine; Pyridine, 4-iodo-2-(1-methylethoxy)-; 4-Iodo-2-isopropoxy-pyridine; 1353777-52-2; 4-Iodo-2-(isopropoxy)pyridine
EINECS	Contact for details

Quality Control

Our 4-Iodo-2-Isopropoxypyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.