Description

1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)-1H-Pyrazole is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is essential for R&D and production in the pharmaceutical, agrochemical, and materials science industries, where precise molecular control is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and pyrazole motifs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its unique chemical structure for enhanced bioactivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where the boronic ester group facilitates polymerization and functionalization.
• Chemical Biology & Medicinal Chemistry: Acts as a versatile probe and building block for creating compound libraries in drug discovery programs targeting various disease pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for the production of bespoke, high-value specialty chemicals on a commercial scale.

Basic Information

Product Name	1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)-1H-Pyrazole
CAS No.	1353003-51-6
Molecular Formula	C11H16BF3N2O2
Molecular Weight	276.07 g/mol
Synonyms	1-Methyl-5-(trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole; 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyrazole; 5-(Trifluoromethyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; Pyrazole boronic ester, trifluoromethyl-substituted; CAS 1353003-51-6
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.