Description

Methyl 4-Bromo-5-Fluoro-2-Methylbenzoate is a high-purity fluorinated and brominated aromatic ester, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile molecular scaffold for constructing complex pharmacophores and functional materials. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce halogenated aromatic motifs into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting kinase inhibitors, anti-cancer agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the bromo and fluoro substituents enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, enabling rapid diversification of the aromatic ring.
• Functional Polymer Monomer: Can be incorporated into polymer backbones to impart specific properties such as altered solubility, thermal stability, or electronic characteristics.
• Chemical Research & Development: A valuable reagent for academic and industrial research in exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	Methyl 4-Bromo-5-Fluoro-2-Methylbenzoate
CAS No.	1352889-89-4
Molecular Formula	C10H10BrFO2
Molecular Weight	261.09 g/mol
Synonyms	4-Bromo-5-fluoro-2-methylbenzoic acid methyl ester; Methyl 4-bromo-5-fluoro-o-toluate; Benzoic acid, 4-bromo-5-fluoro-2-methyl-, methyl ester; 2-Methyl-4-bromo-5-fluorobenzoic acid methyl ester; Methyl 4-bromo-5-fluoro-2-methylbenzenecarboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-Bromo-5-Fluoro-2-Methylbenzoate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.