Description

4-Methyl-2-((Tetrahydrofuran-3-Yl)Oxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical advanced pharmaceutical intermediate and cross-coupling reagent in modern synthetic chemistry. Its molecular architecture, featuring a protected boronate group and a pyridine core linked via a tetrahydrofuran-ether bridge, makes it indispensable for constructing complex molecules with precision. This compound is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for creating biaryl and heterobiaryl structures prevalent in drug candidates.
• Pharmaceutical Intermediate: Used in the synthesis of targeted therapies, including kinase inhibitors and other small molecule drugs.
• Agrochemical Research: Serves as a precursor in developing novel herbicides, fungicides, and insecticides with specific modes of action.
• Material Science: Potential monomer or precursor for synthesizing functional polymers and organic electronic materials.
• Chemical Biology & Proteomics: Can be utilized as a probe or linker in bioconjugation and activity-based protein profiling.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for bespoke synthesis projects requiring specific boronate functionalities.

Basic Information

Product Name	4-Methyl-2-((Tetrahydrofuran-3-Yl)Oxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1352741-89-9
Molecular Formula	C17H26BNO4
Molecular Weight	319.21 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-((tetrahydrofuran-3-yl)oxy)-4-methylpyridine; 2-((Tetrahydrofuran-3-yl)oxy)-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Methyl-2-(tetrahydrofuran-3-yloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-yl) tetrahydrofuran-3-yl ether; CAS 1352741-89-9
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2-((Tetrahydrofuran-3-Yl)Oxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. Due to its hygroscopic and easily oxidized nature, the container must be sealed immediately after use to minimize exposure to moisture and air. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.