Description

5-Amino-2-Cbz-2-Azaspiro[3.3]Heptane is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and three-dimensional complexity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutics, particularly in areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) targeting complex diseases.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around constrained spirocyclic architectures.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the design of bifunctional molecules for targeted protein degradation.
• CNS Drug Discovery: Employed in the development of compounds intended to cross the blood-brain barrier for treating neurological conditions.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scalable production of client-specific drug candidates under cGMP conditions.

Basic Information

Product Name	5-Amino-2-Cbz-2-Azaspiro[3.3]Heptane
CAS No.	1352546-87-2
Molecular Formula	C15H20N2O2
Molecular Weight	260.34 g/mol
Synonyms	5-Amino-2-[(benzyloxy)carbonyl]-2-azaspiro[3.3]heptane; 2-Azaspiro[3.3]heptane-2-carboxylic acid, 5-amino-, benzyl ester; 2-Cbz-5-Amino-2-azaspiro[3.3]heptane; Benzyl 5-amino-2-azaspiro[3.3]heptane-2-carboxylate; 5-Amino-2-(Cbz)-2-azaspiro[3.3]heptane; 5-Amino-2-(benzyloxycarbonyl)-2-azaspiro[3.3]heptane; 2-Cbz-5-Amino-2-azaspiro[3.3]heptane-6-carboxylic acid (related derivative); Spirocyclic Cbz-protected amine.
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-2-Cbz-2-Azaspiro[3.3]Heptane is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical R&D and scale-up. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC purity, NMR, and MS data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.