Description

5-(Boc-Amino)-2-Azaspiro[3.3]Heptane is a high-value, protected amine building block featuring a rigid spirocyclic scaffold, essential for modern drug discovery. This compound is a critical intermediate in the synthesis of novel pharmaceuticals, particularly for creating conformationally constrained molecules with improved metabolic stability and target selectivity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for research and development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drugs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Proteolysis Targeting Chimera (PROTAC) Development: Used to construct linkers and warhead components due to its three-dimensional structure and amine functionality.
• Peptidomimetic Chemistry: Incorporates rigidity into peptide backbones to enhance bioavailability and receptor binding affinity.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study enzyme function and protein-protein interactions.
• Agrochemical Research: Potential intermediate in the development of novel active ingredients with unique modes of action.
• Academic & Contract Research: Employed in university and CRO settings for exploratory synthetic chemistry and methodology development.

Basic Information

Product Name	5-(Boc-Amino)-2-Azaspiro[3.3]Heptane
CAS No.	1352546-72-5
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	tert-Butyl (2-azaspiro[3.3]heptan-5-yl)carbamate; 2-Azaspiro[3.3]heptane-5-carboxamide, N-(1,1-dimethylethoxy)-; 5-((tert-Butoxycarbonyl)amino)-2-azaspiro[3.3]heptane; 5-(Boc-NH)-2-Azaspiro[3.3]heptane; Boc-2-Azaspiro[3.3]heptan-5-amine; 2-Azaspiro[3.3]heptan-5-amine, N-Boc-protected; 1352546-72-5
EINECS	Contact for details

Quality Control

Our 5-(Boc-Amino)-2-Azaspiro[3.3]Heptane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to prevent degradation upon repeated opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.