Description

2-(6-Chloro-Pyridin-3-Yl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, particularly in the creation of active pharmaceutical ingredients (APIs) with pyrrolidine and pyridine pharmacophores. It is essential for R&D chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors who require reliable, high-quality intermediates for scale-up and production.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the research and development of advanced crop protection agents and pesticides.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and contract research organizations (CROs/CMOs).
• Academic Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	2-(6-Chloro-Pyridin-3-Yl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1352534-35-0
Molecular Formula	C14H19ClN2O2
Molecular Weight	282.77 g/mol
Synonyms	tert-Butyl 2-(6-chloropyridin-3-yl)pyrrolidine-1-carboxylate; 1-Boc-2-(6-chloro-3-pyridyl)pyrrolidine; 2-(6-Chloro-3-pyridinyl)-1-(1,1-dimethylethoxycarbonyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-2-(6-chloropyridin-3-yl)pyrrolidine; 2-(6-Chloro-3-pyridyl)-1-N-Boc-pyrrolidine; Pyrrolidine-1-carboxylic acid, 2-(6-chloro-3-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-(6-Chloro-Pyridin-3-Yl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent quality suitable for research and scale-up. Certificates of Analysis (COA) with full analytical data are provided to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.