Description

4-(2,4-Dioxo-1,3-Diaza-Spiro[4.5]Dec-3-Yl)-Benzoic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic hydantoin scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for oncology, neurology, and metabolic disease applications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop novel bioactive molecules.
• Protease Inhibitor Development: The spirocyclic hydantoin core is a privileged structure in the design of enzyme inhibitors.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds to study biological processes and identify new drug targets.
• Custom Synthesis: Employed in contract research and manufacturing (CRAM) for client-specific molecule assembly.

Basic Information

Product Name	4-(2,4-Dioxo-1,3-Diaza-Spiro[4.5]Dec-3-Yl)-Benzoic Acid Ethyl Ester
CAS No.	1352517-28-2
Molecular Formula	C18H22N2O4
Molecular Weight	330.38 g/mol
Synonyms	Ethyl 4-(2,4-dioxo-1,3-diaza-spiro[4.5]dec-3-yl)benzoate; Benzoic acid, 4-(2,4-dioxo-1,3-diaza-spiro[4.5]dec-3-yl)-, ethyl ester; 1,3-Diaza-spiro[4.5]decane-2,4-dione, 3-[4-(ethoxycarbonyl)phenyl]-; 3-[4-(Ethoxycarbonyl)phenyl]-1,3-diaza-spiro[4.5]decane-2,4-dione; 4-(2,4-Dioxo-1,3-diazaspiro[4.5]dec-3-yl)benzoic acid ethyl ester; Spiro[4.5]decane-1,3-dione derivative; Ethyl 4-(2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)benzoate
EINECS	Contact for details

Quality Control

Our 4-(2,4-Dioxo-1,3-Diaza-Spiro[4.5]Dec-3-Yl)-Benzoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.