Description

4-Methyl-2-(4-Methylpiperidin-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, which is critical for modern synthetic methodologies. This compound matters because it serves as a versatile building block in cross-coupling reactions, enabling the efficient construction of complex molecules for drug discovery and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to create novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl and heterobiaryl structures prevalent in modern pharmaceuticals.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides that require specific, complex heterocyclic architectures.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular engineering is required.
• Medicinal Chemistry Library Construction: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Provides a reliable and scalable intermediate for transitioning from laboratory-scale discovery to pilot and commercial manufacturing processes.

Basic Information

Product Name	4-Methyl-2-(4-Methylpiperidin-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1352414-66-4
Molecular Formula	C18H29BN2O2
Molecular Weight	316.25 g/mol
Synonyms	2-(4-Methyl-1-piperidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-picoline; 4-Methyl-2-(4-methylpiperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(4-methyl-1-piperidinyl)-4-methylpyridine; CAS 1352414-66-4; 4-Methyl-2-(4-methyl-1-piperidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol ester of [4-Methyl-2-(4-methylpiperidin-1-yl)pyridin-5-yl]boronic acid
EINECS	Contact for details

Quality Control

Every batch of our 4-Methyl-2-(4-Methylpiperidin-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocols are designed to support cGMP and ISO 9001 compliant manufacturing environments. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.